Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 7/20 | 0.47 |
| ▸ | GSK3B | P49841 | 6/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.43 |
| ▸ | CDK2 | P24941 | 5/20 | 0.42 |
| ▸ | JUN | P05412 | 2/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8235105 | 0.91 | CDK4 (0.51) | CDK4GSK3BMAPK8MAPK9MAPK10 | |
| SCHEMBL8227614 | 0.79 | MAPK9 (0.57) | CDK4GSK3BMAPK8MAPK9MAPK10 | |
| SCHEMBL5315804 | 0.74 | CDK4 (0.47) | CDK4GSK3BMAPK8MAPK9MAPK10 | |
| SCHEMBL5315799 | 0.74 | CDK4 (0.47) | CDK4GSK3BMAPK8MAPK9MAPK10 | |
| SCHEMBL5336074 | 0.73 | CDK4 (0.51) | CDK4GSK3BMAPK8MAPK9MAPK10 | |
| SCHEMBL5336071 | 0.73 | CDK4 (0.51) | CDK4GSK3BMAPK8MAPK9MAPK10 | |
| SCHEMBL8233932 | 0.73 | CDK1 (0.56) | CDK4GSK3BIRAK4MAPK8MAPK9 | |
| SCHEMBL8233938 | 0.72 | MAPK8 (0.54) | CDK4GSK3BMAPK8MAPK9MAPK10 | |
| SCHEMBL5315259 | 0.72 | MAPK8 (0.54) | CDK4GSK3BMAPK8MAPK9MAPK10 | |
| SCHEMBL5315255 | 0.72 | MAPK8 (0.54) | CDK4GSK3BMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |