Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 3/20 | 0.53 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.53 |
| ▸ | AR | P10275 | 3/20 | 0.53 |
| ▸ | PGR | P06401 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4286486 | 0.81 | NR3C2 (0.80) | NR3C1NR3C2ARPGRMAPT | |
| SCHEMBL4286619 | 0.70 | NR3C2 (0.85) | NR3C1NR3C2ARPGRMAPT | |
| SCHEMBL4293554 | 0.69 | NR3C2 (1.00) | NR3C1NR3C2ARPGRMAPT | |
| SCHEMBL4299922 | 0.69 | NR3C2 (0.82) | NR3C1NR3C2ARPGRMAPT | |
| SCHEMBL4295535 | 0.62 | NR3C2 (0.77) | NR3C1NR3C2ARPGRMAPT | |
| SCHEMBL3434341 | 0.58 | MAPT (0.82) | MAPTMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL10653418 | 0.56 | CA2 (0.53) | MAPTMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL4288508 | 0.56 | NR3C2 (0.67) | NR3C1NR3C2ARPGRMAPT | |
| SCHEMBL4287386 | 0.56 | NR3C2 (0.70) | NR3C1NR3C2ARPGRMAPT | |
| SCHEMBL11333989 | 0.56 | MAPT (0.63) | MAPTMEN1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077961-A2 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-07-12 | — | — | WO | disclosed |