Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21360338 | 1.00 | GPR119 (0.52) | GPR119JAK2JAK1KDM4EPKM | |
| SCHEMBL21360343 | 0.90 | GPR119 (0.50) | GPR119JAK2JAK1KDM4EPKM | |
| SCHEMBL31484639 | 0.90 | GPR119 (0.52) | GPR119JAK2JAK1KDM4EPKM | |
| SCHEMBL6719421 | 0.89 | GPR119 (0.43) | GPR119KDM4ESMARCA2SMARCA4PBRM1 | |
| SCHEMBL6719383 | 0.89 | GPR119 (0.43) | GPR119KDM4ESMARCA2SMARCA4PBRM1 | |
| SCHEMBL18186285 | 0.88 | NR1H2 (0.44) | GPR119USP30SMARCA2SMARCA4PBRM1 | |
| SCHEMBL21360346 | 0.88 | GRM5 (0.42) | GPR119NR1H2TP53 | |
| SCHEMBL38661133 | 0.88 | GPR119 (0.48) | GPR119USP30SMARCA2SMARCA4PBRM1 | |
| SCHEMBL16825013 | 0.88 | NR1H2 (0.44) | GPR119USP30SMARCA2SMARCA4PBRM1 | |
| SCHEMBL14921110 | 0.88 | CNR1 (0.51) | GPR119NR1H2STSTP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007034445-A2 | NOVEL PIPERAZINE DERIVATIVES AS RENIN INHIBITORS FOR CARDIOVASCULAR EVENTS AND RENAL INSUFFICIENCY | ACTELION PHARMACEUTICALS LTD (CH) | 2007-03-29 | — | — | WO | disclosed |