Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | NCS1 | P62166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8234095 | 0.91 | NPC1 (0.55) | NPC1RAB9AKMT2ARXFP1MITF | |
| SCHEMBL8234328 | 0.91 | NPC1 (0.43) | NPC1RAB9AKMT2ARXFP1MITF | |
| SCHEMBL8234407 | 0.91 | MAPT (0.46) | NPC1RAB9AKMT2ARXFP1TP53 | |
| SCHEMBL645446 | 0.91 | ABCB1 (0.44) | NPC1RAB9AKMT2ARXFP1ABCB1 | |
| SCHEMBL649492 | 0.86 | NPC1 (0.51) | NPC1RAB9AKMT2ARXFP1MITF | |
| SCHEMBL8233835 | 0.86 | LOXL2 (0.39) | NPC1RAB9ATP53GAAKDM4E | |
| SCHEMBL648256 | 0.85 | RAB9A (0.42) | NPC1RAB9AKMT2ARXFP1MITF | |
| SCHEMBL649511 | 0.85 | RAB9A (0.44) | NPC1RAB9AKMT2ARXFP1MITF | |
| SCHEMBL8233863 | 0.85 | EPHX2 (0.42) | NPC1RAB9AMITFTP53KDM4E | |
| SCHEMBL648285 | 0.84 | KMT2A (0.46) | NPC1RAB9AKMT2ARXFP1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109362-A2 | BENZOIMIDAZOLYL-PARAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-09-27 | — | — | WO | disclosed |