Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PLK1 | P53350 | 8/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL250247 | 0.85 | HDAC6 (0.80) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL479724 | 0.81 | HDAC2 (0.67) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL424293 | 0.79 | HDAC8 (0.64) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL16198923 | 0.78 | HDAC6 (0.70) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL14115137 | 0.78 | HDAC6 (0.70) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL6100 | 0.78 | HDAC8 (0.62) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL25489176 | 0.77 | HDAC8 (0.61) | HDAC8HDAC6HDAC2HPGDTSHR | |
| SCHEMBL10759601 | 0.77 | HDAC8 (0.61) | HDAC8HDAC6HDAC2HPGDTSHR | |
| Hydrochloric Acid SCHEMBL5866386 | 0.76 | HDAC8 (0.60) | HDAC8HDAC6HDAC2HPGDTSHR | |
| Methane SCHEMBL15893673 | 0.76 | HDAC8 (0.67) | HDAC8HDAC6HDAC2HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007036733-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |