Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 1/20 | 0.46 |
| ▸ | GPR52 | Q9Y2T5 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | RORB | Q92753 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049839 | 0.87 | IL2 (0.59) | IL2GPR52ALDH1A1SMN1; SMN2PIK3CD | |
| SCHEMBL8239548 | 0.87 | IL2 (0.46) | IL2ALDH1A1SMN1; SMN2PIK3CDPIK3CA | |
| SCHEMBL8237636 | 0.84 | IL2 (0.46) | IL2ALDH1A1SMN1; SMN2RORBKMT2A | |
| SCHEMBL8239902 | 0.82 | IL2 (0.41) | IL2GPR52ALDH1A1SMN1; SMN2RORB | |
| SCHEMBL8240359 | 0.81 | IL2 (0.45) | IL2GPR52ALDH1A1SMN1; SMN2RORB | |
| SCHEMBL48415 | 0.81 | PIK3CD (0.61) | GPR52ALDH1A1SMN1; SMN2PIK3CDPIK3CA | |
| SCHEMBL5133676 | 0.78 | GPR52 (0.44) | IL2GPR52ALDH1A1SMN1; SMN2PIK3CD | |
| SCHEMBL5049038 | 0.77 | IL2 (0.55) | IL2ALDH1A1SMN1; SMN2RORBGAA | |
| SCHEMBL5524865 | 0.76 | IL2 (0.54) | IL2GPR52ALDH1A1SMN1; SMN2RORB | |
| SCHEMBL5052631 | 0.76 | KMT2A (0.48) | IL2GPR52ALDH1A1SMN1; SMN2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007087427-A2 | THIAZOLE AND THIADIAZOLE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-08-02 | — | — | WO | disclosed |