Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.40 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8236724 | 0.95 | CHRM2 (0.50) | CHRNB2CHRNA4CHRNA7CHRM2CHRM4 | |
| SCHEMBL14235835 | 0.95 | CHRM2 (0.50) | CHRNB2CHRNA4CHRNA7CHRM2CHRM4 | |
| SCHEMBL14235836 | 0.95 | CHRM2 (0.50) | CHRNB2CHRNA4CHRNA7CHRM2CHRM4 | |
| SCHEMBL2571302 | 0.75 | SCD5 (0.47) | — | |
| SCHEMBL14213445 | 0.74 | SCD5 (0.36) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL14213444 | 0.74 | SCD5 (0.36) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL13180376 | 0.74 | SCD5 (0.39) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL13145789 | 0.74 | SCD5 (0.36) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL14213447 | 0.74 | SCD5 (0.36) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL13085313 | 0.70 | GAA (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006276-B2 | Substituted oxindole derivatives, medicaments containing said derivatives and use thereof | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-04-14 | — | — | US | disclosed |
| US-20130029966-A1 | SUBSTITUTED OXINDOLE DERIVATIVES, MEDICAMENTS CONTAINING SAID DERIVATIVES AND USE THEREOF | ABBOTT GMBH & CO. KG (DE) | 2013-01-31 | — | — | US | disclosed |
| US-8044079-B2 | Substituted oxindole derivatives, medicaments containing said derivatives and use thereof | ABBOTT GMBH & CO. KG (DE) | 2011-10-25 | — | — | US | disclosed |
| US-20100273766-A1 | SUBSTITUTED OXINDOL DERIVATIVES, MEDICAMENTS CONTAINING SAID DERIVATIVES AND USE THEREOF | ABBOTT GMBH & CO. KG (DE) | 2010-10-28 | — | — | US | disclosed |
| WO-2007063123-A1 | SUBSTITUTED OXINDOL-DERIVATIVES, MEDICAMENTS CONTAINING SAID DERIVATIVES AND USE THEREOF | ABBOTT GMBH & CO. KG (DE) | 2007-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130029966-A1 | SUBSTITUTED OXINDOLE DERIVATIVES, MEDICAMENTS CONTAINING SAID DERIVATIVES AND USE THEREOF | AVPR2, AVPR1B, AVPR1A | CHRNB2 3020/4885CHRNA4 3526/4885CHRNA7 3234/4885 |
| US-20100273766-A1 | SUBSTITUTED OXINDOL DERIVATIVES, MEDICAMENTS CONTAINING SAID DERIVATIVES AND USE THEREOF | AVPR2, AVPR1B, AVPR1A | CHRNB2 3081/4885CHRNA4 3702/4885CHRNA7 3829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.