Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1764515 | 0.88 | RAB9A (0.64) | GRM5RAB9ANPC1MEN1KMT2A | |
| SCHEMBL8242296 | 0.85 | KDM4E (0.56) | GRM5RAB9ANPC1MEN1KMT2A | |
| SCHEMBL13764343 | 0.84 | GRM5 (0.47) | GRM5RAB9ANPC1MEN1KMT2A | |
| SCHEMBL13764341 | 0.84 | GRM5 (0.47) | GRM5RAB9ANPC1MEN1KMT2A | |
| SCHEMBL11982729 | 0.84 | GRM5 (0.47) | GRM5RAB9ANPC1MEN1KMT2A | |
| SCHEMBL11982616 | 0.84 | ALDH1A1 (0.50) | GRM5RAB9ANPC1MEN1KMT2A | |
| SCHEMBL11982615 | 0.82 | RAB9A (0.50) | GRM5RAB9ANPC1MEN1KMT2A | |
| SCHEMBL13764342 | 0.80 | CYP1A1 (0.52) | GRM5RAB9ANPC1MEN1KMT2A | |
| SCHEMBL11982737 | 0.80 | MAPT (0.54) | GRM5RAB9ANPC1MEN1KMT2A | |
| SCHEMBL8239502 | 0.80 | MPL (0.51) | RAB9ANPC1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007050050-A2 | THIAZOLYL MGLUR5 ANTAGONISTS AND METHODS FOR THEIR USE | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | disclosed |