Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.58 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | RXRG | P48443 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2294409 | 0.90 | FFAR4 (0.56) | LRRK2FFAR4SRPK3RXRARXRB | |
| SCHEMBL2292469 | 0.88 | PPARA (0.51) | LRRK2FFAR4PTPN1SRPK3MRGPRX4 | |
| SCHEMBL8243758 | 0.86 | LRRK2 (0.58) | LRRK2PTPN1SRPK3MRGPRX4RXRA | |
| SCHEMBL17040660 | 0.84 | FFAR4 (0.60) | LRRK2FFAR4MRGPRX4FFAR1 | |
| SCHEMBL30660491 | 0.81 | LRRK2 (0.55) | LRRK2FFAR4SRPK3MRGPRX4RXRA | |
| SCHEMBL26931289 | 0.81 | LRRK2 (0.55) | LRRK2FFAR4SRPK3MRGPRX4RXRA | |
| SCHEMBL1647426 | 0.81 | LRRK2 (0.62) | LRRK2PTPN1SRPK3MRGPRX4RXRA | |
| SCHEMBL2294533 | 0.80 | MRGPRX4 (0.42) | LRRK2FFAR4MRGPRX4KDM4EPPARD | |
| SCHEMBL1646760 | 0.80 | FFAR4 (0.55) | LRRK2FFAR4KDM4EFFAR1MAOB | |
| SCHEMBL30660527 | 0.78 | FFAR4 (0.52) | LRRK2FFAR4SRPK3MRGPRX4RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998988-B2 | Biphenyl compounds useful in the treatment or prevention of cardiovascular disorders | BAYER SCHERING PHARMA AKTIENGELLSCHAFT (DE) | 2011-08-16 | — | — | US | disclosed |
| US-20090227640-A1 | Heterocyclic compounds with carboxyl isostere groups and their use for the treatment of cardiovascular diseases | BAYER HEALTHCARE AG (DE) | 2009-09-10 | — | — | US | disclosed |
| WO-2007045366-A1 | HETEROCYCLIC COMPOUNDS WITH CARBOXYL ISOSTERE GROUPS AND THEIR USE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227640-A1 | Heterocyclic compounds with carboxyl isostere groups and their use for the treatment of cardiovascular diseases | TNNI3, PC, TNNT2 | LRRK2 3897/4885FFAR4 2560/4885PTPN1 3484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.