Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ARG1 | P05089 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ARG2 | P78540 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28655000 | 1.00 | TDP1 (0.54) | TDP1ARG1KMT2ATSHRCYP2D6 | |
| SCHEMBL28654997 | 1.00 | TDP1 (0.54) | TDP1ARG1KMT2ATSHRCYP2D6 | |
| SCHEMBL3220227 | 0.90 | EPHX1 (0.52) | TDP1KMT2ATSHRCYP2D6EPHX1 | |
| SCHEMBL27770664 | 0.90 | EPHX1 (0.52) | TDP1KMT2ATSHRCYP2D6EPHX1 | |
| SCHEMBL8596277 | 0.89 | KMT2A (0.57) | TDP1ARG1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL15623782 | 0.85 | ARG1 (0.41) | TDP1ARG1KMT2ATSHRCYP2D6 | |
| SCHEMBL12310946 | 0.84 | ARG1 (0.50) | TDP1ARG1KMT2ATSHRCYP2D6 | |
| SCHEMBL16559588 | 0.84 | ARG1 (0.50) | TDP1ARG1KMT2ATSHRCYP2D6 | |
| SCHEMBL1107035 | 0.83 | TDP1 (0.52) | TDP1KMT2ATSHRCYP2D6EPHX1 | |
| SCHEMBL19974699 | 0.82 | TDP1 (0.48) | TDP1ARG1KMT2ATSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298278-A1 | INHIBITORS OF BETA-SECRETASE FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-11-25 | — | — | US | disclosed |
| US-20100298278-A1 | INHIBITORS OF BETA-SECRETASE FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-11-25 | — | — | US | disclosed |
| US-20100144681-A1 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BOEHRINGER INGELHEIM INTERNATION GMNB (DE) | 2010-06-10 | — | — | US | disclosed |
| US-20100144681-A1 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BOEHRINGER INGELHEIM INTERNATION GMNB (DE) | 2010-06-10 | — | — | US | disclosed |
| US-20090042867-A1 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | FUCHS KLAUS | 2009-02-12 | — | — | US | disclosed |
| US-20090042867-A1 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | FUCHS KLAUS | 2009-02-12 | — | — | US | disclosed |
| WO-2007017509-A1 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-15 | — | — | WO | disclosed |
| WO-2007017507-A1 | BETA-SECRETASE INHIBITORS FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-15 | — | — | WO | disclosed |
| WO-2007017511-A2 | COMPOUNDS FOR TREATING ALZHEIMER'S DISEASE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298278-A1 | INHIBITORS OF BETA-SECRETASE FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BACE1, BACE2, PSEN1 | TDP1 119/4885ARG1 1629/4885KMT2A 2558/4885 |
| US-20090042867-A1 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | PSEN1, PSEN2, MAOB | TDP1 600/4885ARG1 399/4885KMT2A 1906/4885 |
| US-20100144681-A1 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | PSEN1, PSEN2, ADORA3 | TDP1 598/4885ARG1 263/4885KMT2A 1857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.