Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL826914 | 0.99 | LMNA (0.47) | LMNAHTTPDE5AACP1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL826574 | 0.85 | PDE5A (0.40) | LMNAHTTPDE5ASMN1; SMN2TP53 | |
| SCHEMBL823842 | 0.82 | CTPS1 (0.45) | LMNASMN1; SMN2TP53CYP2D6CTPS1 | |
| Hydrochloric Acid SCHEMBL826763 | 0.81 | CTPS1 (0.44) | LMNASMN1; SMN2TP53CYP2D6CTPS1 | |
| Hydrochloric Acid SCHEMBL826665 | 0.79 | SMN1; SMN2 (0.53) | LMNAHTTSMN1; SMN2TP53CYP2D6 | |
| Hydrochloric Acid SCHEMBL826687 | 0.79 | MEN1 (0.56) | LMNAHTTSMN1; SMN2TP53CYP2D6 | |
| Hydrochloric Acid SCHEMBL825798 | 0.77 | SMN1; SMN2 (0.51) | LMNAHTTSMN1; SMN2TP53CYP2D6 | |
| Hydrochloric Acid SCHEMBL826386 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2TP53CYP2D6ALDH1A1CTPS1 | |
| Hydrochloric Acid SCHEMBL826086 | 0.77 | CTPS1 (0.52) | LMNAHTTPDE5ASMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL826314 | 0.76 | SMN1; SMN2 (0.38) | LMNAPDE5ASMN1; SMN2TP53CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143296-B2 | Thiazole-based compound and inhibitor of T-type calcium channel containing the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-03-27 | — | — | US | disclosed |
| US-8143296-B2 | Thiazole-based compound and inhibitor of T-type calcium channel containing the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-03-27 | — | — | US | disclosed |
| US-20100179201-A1 | NOVEL THIAZOLE-BASED COMPOUND AND INHIBITOR OF T-TYPE CALCIUM CHANNEL CONTAINING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-07-15 | — | — | US | disclosed |
| US-20100179201-A1 | NOVEL THIAZOLE-BASED COMPOUND AND INHIBITOR OF T-TYPE CALCIUM CHANNEL CONTAINING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179201-A1 | NOVEL THIAZOLE-BASED COMPOUND AND INHIBITOR OF T-TYPE CALCIUM CHANNEL CONTAINING THE SAME | CACNA1G, CACNA1I, CACNA1H | LMNA 2653/4885HTT 687/4885PDE5A 3089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.