Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8963892 | 0.76 | OPRD1 (0.68) | OPRD1HPGDLMNAOPRM1CYP2D6 | |
| SCHEMBL12896029 | 0.72 | OGA (0.48) | MEN1KMT2A | |
| SCHEMBL12896031 | 0.70 | HDAC1 (0.54) | — | |
| SCHEMBL11775241 | 0.68 | MEN1 (0.53) | OPRD1CYP2D6MEN1KMT2A | |
| SCHEMBL23188717 | 0.66 | LMNA (0.51) | LMNATACR1RECQLOPRM1CYP2D6 | |
| SCHEMBL31376561 | 0.66 | LMNA (0.51) | LMNATACR1RECQLOPRM1CYP2D6 | |
| SCHEMBL1629743 | 0.66 | LMNA (0.51) | LMNATACR1RECQLOPRM1CYP2D6 | |
| SCHEMBL27407639 | 0.65 | CYP3A4 (0.47) | LMNACYP2D6MEN1KMT2A | |
| SCHEMBL12473965 | 0.65 | MEN1 (0.58) | OPRD1CYP2D6MEN1KMT2A | |
| SCHEMBL15186926 | 0.64 | OPRD1 (0.49) | OPRD1TACR1OPRM1CYP2D6CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007082880-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-26 | — | — | WO | disclosed |