Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 0.56 |
| ▸ | AKT2 | P31751 | 9/20 | 0.50 |
| ▸ | AKT3 | Q9Y243 | 8/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857030 | 0.72 | IKBKB (0.47) | AKT1PRKCIROCK1 | |
| SCHEMBL2240671 | 0.70 | AURKB (0.71) | PRKCIROCK1 | |
| SCHEMBL858844 | 0.68 | IKBKB (0.64) | PRKCIROCK1 | |
| SCHEMBL4582969 | 0.68 | AKT1 (1.00) | AKT1AKT2AKT3 | |
| SCHEMBL859116 | 0.67 | NUDT1 (0.58) | PRKCIROCK1 | |
| SCHEMBL99690 | 0.67 | PRKCI (1.00) | AKT2PRKCIROCK1 | |
| SCHEMBL29431169 | 0.67 | PRKCI (1.00) | AKT2PRKCIROCK1 | |
| SCHEMBL857778 | 0.67 | NUDT1 (0.64) | PRKCIROCK1 | |
| SCHEMBL634449 | 0.66 | KMT2A (0.56) | PRKCIROCK1 | |
| SCHEMBL29957150 | 0.66 | KMT2A (0.56) | PRKCIROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |