Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ATF4 | P18848 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CPT2 | P23786 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 1/20 | 0.36 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | AOC2 | O75106 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65663 | 0.84 | ALDH1A1 (0.46) | SMN1; SMN2L3MBTL1ATF4RAB9AALDH1A1 | |
| SCHEMBL57050 | 0.79 | KMT2A (0.47) | SMN1; SMN2L3MBTL1ATF4RAB9AALDH1A1 | |
| SCHEMBL66069 | 0.79 | TDP1 (0.47) | SMN1; SMN2L3MBTL1ATF4RAB9AALDH1A1 | |
| SCHEMBL66545 | 0.78 | ALDH1A1 (0.48) | SMN1; SMN2L3MBTL1ATF4RAB9AALDH1A1 | |
| SCHEMBL56480 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2L3MBTL1ATF4RAB9AALDH1A1 | |
| SCHEMBL8243869 | 0.78 | SMN1; SMN2 (0.43) | SMN1; SMN2L3MBTL1ATF4RAB9AALDH1A1 | |
| SCHEMBL65760 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1ATF4RAB9AALDH1A1 | |
| SCHEMBL56987 | 0.73 | KMT2A (0.51) | SMN1; SMN2L3MBTL1ATF4ALDH1A1GAA | |
| SCHEMBL8236980 | 0.67 | ALDH1A1 (0.51) | SMN1; SMN2L3MBTL1RAB9AALDH1A1MAPT | |
| SCHEMBL19702678 | 0.65 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1ATF4RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007050522-A1 | DERIVATIVES FOR MODULATION OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-05-03 | — | — | WO | disclosed |