Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.56 |
| ▸ | ITK | Q08881 | 7/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.49 |
| ▸ | WNT1 | P04628 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK3 | P49761 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5915925 | 0.86 | LRRK2 (0.53) | LRRK2 | |
| SCHEMBL952067 | 0.82 | DYRK1A (0.55) | LRRK2DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL5945615 | 0.81 | FLT3 (0.60) | DYRK1AWNT1 | |
| SCHEMBL6221471 | 0.80 | DYRK1A (0.62) | LRRK2ITKDYRK1AWNT1AURKA | |
| SCHEMBL82789 | 0.80 | DYRK1A (0.52) | LRRK2ITKDYRK1AWNT1CLK2 | |
| SCHEMBL16163220 | 0.79 | ITK (0.79) | LRRK2ITKAURKA | |
| SCHEMBL6221997 | 0.76 | DYRK1A (0.67) | LRRK2DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL5916085 | 0.74 | DYRK1A (0.48) | LRRK2ITKDYRK1AWNT1CLK2 | |
| SCHEMBL14785564 | 0.74 | DYRK1A (0.69) | LRRK2DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL14804593 | 0.73 | DYRK1A (0.70) | LRRK2DYRK1AWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4762543-B2 | — | — | 2011-08-31 | — | — | JP | claimed |
| EP-1549620-A1 | INDAZOLECARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF AS CDK1, CDK2 AND CDK4 INHIBITORS | Sanofi-Aventis (FR) | 2005-07-06 | — | — | EP | claimed |
| WO-2004031158-A1 | INDAZOLECARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF AS CDK1, CDK2 AND CDK4 INHIBITORS | SANOFI-AVENTIS (FR) | 2004-04-15 | — | — | WO | claimed |
| EP-1549620-A1 | INDAZOLECARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF AS CDK1, CDK2 AND CDK4 INHIBITORS | Sanofi-Aventis (FR) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004031158-A1 | INDAZOLECARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF AS CDK1, CDK2 AND CDK4 INHIBITORS | SANOFI-AVENTIS (FR) | 2004-04-15 | — | — | WO | disclosed |