Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.66 |
| ▸ | RAB9A | P51151 | 6/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8246044 | 0.93 | RAB9A (0.56) | SMN1; SMN2RAB9AKDM4ELMNANPC1 | |
| SCHEMBL8242081 | 0.82 | SMN1; SMN2 (0.73) | SMN1; SMN2RAB9AKDM4ELMNANPC1 | |
| SCHEMBL13942531 | 0.79 | RAB9A (0.45) | SMN1; SMN2RAB9AKDM4ELMNANPC1 | |
| SCHEMBL19000704 | 0.77 | SMN1; SMN2 (0.70) | SMN1; SMN2RAB9AKDM4ELMNANPC1 | |
| SCHEMBL13942533 | 0.77 | RAB9A (0.43) | SMN1; SMN2RAB9AKDM4ELMNANPC1 | |
| SCHEMBL13942552 | 0.76 | RAB9A (0.41) | SMN1; SMN2RAB9AKDM4ELMNANPC1 | |
| SCHEMBL4172546 | 0.75 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9AKDM4ELMNANPC1 | |
| SCHEMBL13942551 | 0.75 | RAB9A (0.42) | SMN1; SMN2RAB9AKDM4ELMNANPC1 | |
| SCHEMBL8243863 | 0.75 | RAB9A (0.91) | SMN1; SMN2RAB9AKDM4ELMNANPC1 | |
| SCHEMBL4173129 | 0.73 | RAB9A (0.47) | SMN1; SMN2RAB9AKDM4ELMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007014226-A2 | COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATION AND STROKE | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2007-02-01 | — | — | WO | disclosed |