Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.91 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.91 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.91 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | CNR2 | P34972 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17074602 | 0.90 | RAB9A (0.85) | RAB9ASMN1; SMN2KDM4EHTTCYP1A2 | |
| SCHEMBL8247744 | 0.83 | SMN1; SMN2 (0.63) | RAB9ASMN1; SMN2KDM4EHTTCYP1A2 | |
| SCHEMBL8242081 | 0.80 | SMN1; SMN2 (0.73) | RAB9ASMN1; SMN2KDM4EHTTCYP1A2 | |
| SCHEMBL19000704 | 0.78 | SMN1; SMN2 (0.70) | RAB9ASMN1; SMN2KDM4EHTTCYP1A2 | |
| SCHEMBL17074609 | 0.76 | CNR2 (0.81) | RAB9ASMN1; SMN2KDM4EHTTCYP1A2 | |
| SCHEMBL8245374 | 0.75 | SMN1; SMN2 (0.66) | RAB9ASMN1; SMN2KDM4EHTTCYP1A2 | |
| SCHEMBL13219471 | 0.75 | HTT (0.78) | RAB9ASMN1; SMN2KDM4EHTTCYP1A2 | |
| SCHEMBL17074595 | 0.73 | CNR2 (1.00) | RAB9ASMN1; SMN2KDM4EHTTCYP1A2 | |
| SCHEMBL9982691 | 0.73 | KDM4E (0.64) | RAB9ASMN1; SMN2KDM4ECNR2 | |
| SCHEMBL8243861 | 0.73 | CA12 (0.62) | RAB9ASMN1; SMN2KDM4EHTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012088-A1 | Compounds for the Treatment of Neurodegeneration and Stroke | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2009-01-08 | — | — | US | disclosed |
| US-20090012088-A1 | Compounds for the Treatment of Neurodegeneration and Stroke | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2009-01-08 | — | — | US | disclosed |
| US-20070032496-A1 | Compounds for the Treatment of Neurodegeneration and Stroke | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2007-02-08 | — | — | US | disclosed |
| US-20070032496-A1 | Compounds for the Treatment of Neurodegeneration and Stroke | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2007-02-08 | — | — | US | disclosed |
| WO-2007014226-A2 | COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATION AND STROKE | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2007-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032496-A1 | Compounds for the Treatment of Neurodegeneration and Stroke | PARP1, PARP12, PARP11 | RAB9A 2534/4885SMN1; SMN2 89/4885KDM4E 3160/4885 |
| US-20090012088-A1 | Compounds for the Treatment of Neurodegeneration and Stroke | PARP1, PARP12, PARP11 | RAB9A 2534/4885SMN1; SMN2 89/4885KDM4E 3160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.