Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 4/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31294583 | 0.86 | POLB (0.43) | NPSR1MAPTKMT2AMEN1LMNA | |
| SCHEMBL8243599 | 0.81 | APLNR (0.43) | APLNRFPR2MAPTLMNAALDH1A1 | |
| SCHEMBL12603183 | 0.81 | APLNR (0.41) | APLNRNPSR1MAPTKMT2AMEN1 | |
| SCHEMBL8243400 | 0.79 | APLNR (0.43) | APLNRFPR2ALOX5NPSR1MAPT | |
| SCHEMBL13451133 | 0.78 | PDE2A (0.40) | APLNRALOX5NPSR1MAPTKMT2A | |
| SCHEMBL31192692 | 0.78 | APLNR (0.42) | APLNRALOX5NPSR1MAPTKMT2A | |
| SCHEMBL14720356 | 0.78 | APLNR (0.42) | APLNRFPR2ALOX5NPSR1MAPT | |
| SCHEMBL11546401 | 0.78 | PPARA (0.39) | S1PR1HPGD | |
| SCHEMBL21834354 | 0.78 | NPSR1 (0.41) | ALOX5NPSR1MAPTKMT2AMEN1 | |
| SCHEMBL30973037 | 0.78 | NPSR1 (0.41) | ALOX5NPSR1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007050576-A2 | A METHOD OF PREPARING A 4-OXO-1- (3 SUBSTITUTED PHENYL) -1, 4-DIHYDRO-1, 8-NAPHTHYRIDINE-3- CARBOXAMIDE PHOSPHODIESTERASE-4 INHIBITOR | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | disclosed |