Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8246538 | 0.89 | ADAMTS4 (0.45) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL8254358 | 0.88 | ADAMTS4 (0.40) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL10165457 | 0.84 | ADAMTS4 (0.36) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL8246226 | 0.82 | ADAMTS4 (0.45) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL8246504 | 0.82 | ADAMTS4 (0.41) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL8255480 | 0.82 | ADAMTS4 (0.41) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL8253969 | 0.81 | ADAMTS4 (0.44) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL10165450 | 0.81 | ADAMTS4 (0.48) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL10165436 | 0.81 | ADAMTS4 (0.42) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL10165452 | 0.80 | MMP13 (0.47) | ADAMTS4MMP3MMP13MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006128184-A2 | PYRIMIDINE OR TRIAZINE FUSED BICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS-PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |