Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.77 |
| ▸ | MMP3 | P08254 | 2/20 | 0.77 |
| ▸ | MMP13 | P45452 | 2/20 | 0.77 |
| ▸ | MMP8 | P22894 | 1/20 | 0.56 |
| ▸ | MMP12 | P39900 | 1/20 | 0.56 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8256338 | 0.91 | MMP13 (0.82) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL8256275 | 0.90 | MMP13 (0.86) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL10166038 | 0.90 | MMP13 (0.74) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL8222933 | 0.90 | MMP13 (0.80) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL10166080 | 0.89 | MMP13 (0.82) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL8255754 | 0.89 | MMP13 (0.80) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL8252163 | 0.89 | ADAMTS4 (0.62) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL8253462 | 0.89 | MMP13 (0.81) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL10167263 | 0.89 | ADAMTS4 (0.73) | ADAMTS4MMP3MMP13MMP8MMP12 | |
| SCHEMBL8246527 | 0.88 | MMP13 (0.76) | ADAMTS4MMP3MMP13MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006128184-A2 | PYRIMIDINE OR TRIAZINE FUSED BICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS-PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |