Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8436676 | 0.82 | C3AR1 (0.50) | RAB9ASMN1; SMN2NPC1CCNCCDK8 | |
| SCHEMBL5257117 | 0.80 | CYP1A2 (0.55) | RAB9ASMN1; SMN2NPC1CCNCCDK8 | |
| SCHEMBL5257113 | 0.80 | CYP1A2 (0.55) | RAB9ASMN1; SMN2NPC1CCNCCDK8 | |
| SCHEMBL23015759 | 0.76 | DYRK1A (0.42) | RAB9ASMN1; SMN2NPC1CCNCCDK8 | |
| SCHEMBL14069904 | 0.68 | NAMPT (0.58) | RAB9ASMN1; SMN2NPC1CYP1A2C3AR1 | |
| SCHEMBL30834271 | 0.67 | CYP1A2 (0.69) | RAB9ASMN1; SMN2NPC1CYP1A2MAOB | |
| SCHEMBL21593634 | 0.67 | DRD2 (0.63) | RAB9ASMN1; SMN2NPC1CYP1A2CNR2 | |
| SCHEMBL7040433 | 0.67 | DRD2 (0.63) | RAB9ASMN1; SMN2NPC1CYP1A2CNR2 | |
| SCHEMBL7040434 | 0.67 | DRD2 (0.63) | RAB9ASMN1; SMN2NPC1CYP1A2CNR2 | |
| SCHEMBL25692405 | 0.67 | NPC1 (0.49) | RAB9ASMN1; SMN2NPC1CNR2SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312334-B2 | Method of preparing inhibitors phosphodiesterase-4 | MERCK & CO. INC. (US) | 2007-12-25 | — | — | US | disclosed |
| US-20040102472-A1 | Method of preparing inhibitors of phosphodiesterase-4 | MERCK & CO., INC. | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102472-A1 | Method of preparing inhibitors of phosphodiesterase-4 | PDE4B, PDE4A, PDE5A | RAB9A 2625/4885SMN1; SMN2 3859/4885NPC1 3077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.