Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | YES1 | P07947 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31458404 | 0.78 | DYRK1A (0.44) | DYRK1AKDM4EMAPK1PTGS2RAF1 | |
| SCHEMBL27497376 | 0.76 | PELI1 (0.46) | DYRK1AKDM4EMAPK1RAF1PKMYT1 | |
| SCHEMBL8247342 | 0.76 | RAB9A (0.51) | PTGS2CCNCCDK8NPC1RAB9A | |
| SCHEMBL18650817 | 0.75 | RXRA (0.50) | KDM4EMAPK1SMN1; SMN2EGFRPELI1 | |
| SCHEMBL30589032 | 0.75 | HCAR2 (0.43) | DYRK1AKDM4EMAPK1RAF1PKMYT1 | |
| SCHEMBL23015760 | 0.74 | PTGS2 (0.51) | DYRK1AKDM4EPTGS2RAF1PKMYT1 | |
| SCHEMBL1381805 | 0.74 | KDM4E (0.70) | KDM4EMAPK1PTGS2NPC1RAB9A | |
| SCHEMBL12894656 | 0.74 | KDM4E (0.70) | KDM4EMAPK1PTGS2NPC1RAB9A | |
| SCHEMBL19262996 | 0.73 | TYR (0.48) | PTGS2AKT1ALDH1A1 | |
| SCHEMBL23015745 | 0.73 | MET (0.37) | DYRK1AKDM4EMAPK1PTGS2CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10927106-B2 | Benzothiazole derivatives as DYRK1 inhibitors | PHARMASUM THERAPEUTICS AS (NO) | 2021-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927106-B2 | Benzothiazole derivatives as DYRK1 inhibitors | DYRK1A, DYRK1B, PDK2 | DYRK1A 1/4885KDM4E 984/4885MAPK1 354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.