Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.56 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12848418 | 0.87 | KMT2A (0.69) | KMT2AMEN1POLBSMN1; SMN2HPGD | |
| SCHEMBL2563246 | 0.83 | SMN1; SMN2 (0.56) | KMT2AMEN1POLBSMN1; SMN2MAPK1 | |
| SCHEMBL24934235 | 0.83 | HSD17B10 (0.67) | KMT2APOLBSMN1; SMN2MAPK1HPGD | |
| SCHEMBL8426765 | 0.82 | HPGD (0.64) | KMT2AMEN1POLBSMN1; SMN2HPGD | |
| SCHEMBL24740256 | 0.82 | SMN1; SMN2 (1.00) | KMT2AMEN1SMN1; SMN2MAPK1HPGD | |
| SCHEMBL27300755 | 0.81 | SMN1; SMN2 (0.77) | KMT2AMEN1POLBSMN1; SMN2MAPK1 | |
| SCHEMBL6538994 | 0.80 | KDM4E (0.62) | KMT2AMEN1POLBSMN1; SMN2MAPK1 | |
| SCHEMBL638456 | 0.80 | SMN1; SMN2 (0.62) | KMT2AMEN1POLBSMN1; SMN2MAPK1 | |
| SCHEMBL11331816 | 0.80 | KMT2A (0.71) | KMT2AMEN1POLBSMN1; SMN2MAPK1 | |
| SCHEMBL11331813 | 0.80 | KMT2A (0.71) | KMT2AMEN1POLBSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504431-B2 | Sulfonyl amide inhibitors of calcium channel function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-17 | — | — | US | disclosed |
| US-20050245535-A1 | Sulfonyl amide inhibitors of calcium channel function | BRISTOL- MYERS SQUIBB COMPANY | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245535-A1 | Sulfonyl amide inhibitors of calcium channel function | CACNA1F, CACNA1A, CACNA1D | KMT2A 3232/4885MEN1 2007/4885POLB 4812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.