Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380860 | 0.90 | MEN1 (0.44) | ALDH1A1SMN1; SMN2MAPTKDM4ETP53 | |
| SCHEMBL823913 | 0.77 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MAPTKDM4ETP53 | |
| SCHEMBL1161082 | 0.71 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2MAPTKDM4ETP53 | |
| SCHEMBL16769196 | 0.70 | DUT (0.37) | ALDH1A1SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL1392926 | 0.70 | MEN1 (0.38) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL10721461 | 0.70 | EGLN3 (0.47) | ALDH1A1SMN1; SMN2MAPTKDM4ETP53 | |
| SCHEMBL20099499 | 0.69 | EGLN3 (0.43) | ALDH1A1SMN1; SMN2MAPTKDM4ETP53 | |
| SCHEMBL738419 | 0.69 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MAPTKDM4ETP53 | |
| SCHEMBL9473307 | 0.69 | ALDH1A1 (0.46) | ALDH1A1KDM4ETDP1TSHRMEN1 | |
| SCHEMBL15147948 | 0.69 | DUT (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143425-B2 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |