Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRHDE | Q9UKU6 | 1/20 | 0.61 |
| ▸ | CPB2 | Q96IY4 | 5/20 | 0.49 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.47 |
| ▸ | ACE | P12821 | 4/20 | 0.47 |
| ▸ | CPB1 | P15086 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 2/20 | 0.44 |
| ▸ | TRHR | P34981 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870099 | 1.00 | TRHDE (0.61) | TRHDECPB2ACE2ACECPB1 | |
| SCHEMBL8248813 | 1.00 | TRHDE (0.61) | TRHDECPB2ACE2ACECPB1 | |
| SCHEMBL5869691 | 0.91 | TRHDE (0.52) | TRHDECPB2ACE2ACECPB1 | |
| SCHEMBL8250239 | 0.91 | TRHDE (0.52) | TRHDECPB2ACE2ACECPB1 | |
| SCHEMBL5869901 | 0.88 | TRHDE (0.52) | TRHDECPB2ACE2ACECPB1 | |
| SCHEMBL8249027 | 0.88 | TRHDE (0.52) | TRHDECPB2ACE2ACECPB1 | |
| SCHEMBL8254696 | 0.87 | TRHDE (0.49) | TRHDECPB2ACE2ACECPB1 | |
| SCHEMBL5869697 | 0.87 | TRHDE (0.49) | TRHDECPB2ACE2ACECPB1 | |
| SCHEMBL21673119 | 0.84 | TRHDE (0.58) | TRHDECPB2CPB1TRHR | |
| SCHEMBL24004542 | 0.82 | TRHDE (0.56) | TRHDECPB2CPB1TRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | TRHDE 3478/4885CPB2 16/4885ACE2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.