TRHDE — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL5870099	0.61	1/20
SCHEMBL8248813	0.61	1/20
SCHEMBL8249152	0.61	1/20
SCHEMBL21673119	0.58	1/20
SCHEMBL11036098	0.57	1/20
SCHEMBL29692716	0.56	1/20
SCHEMBL24004542	0.56	1/20
SCHEMBL26931596	0.56	1/20
SCHEMBL755381	0.54	1/20
SCHEMBL3842771	0.54	1/20
SCHEMBL31035995	0.52	1/20
SCHEMBL3608209	0.52	1/20
SCHEMBL3103486	0.52	1/20
SCHEMBL14347589	0.52	1/20
SCHEMBL17329292	0.52	1/20
SCHEMBL29802269	0.52	1/20
SCHEMBL5869691	0.52	1/20
SCHEMBL5869901	0.52	1/20
SCHEMBL8249027	0.52	1/20
SCHEMBL8250239	0.52	1/20

Clinical trials — most relevant to TRHDE by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Thyroid Medication and Antidepressants for Treating Major Depression	PHASE4	COMPLETED
Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation	PHASE4	COMPLETED
Neurocognitive and Metabolic Effects of Mild Hypothyroidism	PHASE4	COMPLETED
A Study to Learn if Recombinant Human Parathyroid Hormone [rhPTH(1-84)] Can Improve Symptoms and Metabolic Control in Adults With Hypoparathyroidism (BALANCE)	PHASE4	COMPLETED
Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction	PHASE4	COMPLETED
Selenium in Mild Thyroid Eye Disease in North America	PHASE3	WITHDRAWN
Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities	PHASE2	COMPLETED
Thyroid and Glucose and Energy Metabolism	PHASE2	COMPLETED
Study of Resistance to Thyroid Hormone After Long-term Exposure in People With Thyroid Cancer	PHASE1	WITHDRAWN
Natural History of Thyroid Function Disorders	nan	RECRUITING
Quality of Life Among Egyptian Hypothyroid Patients	nan	UNKNOWN
Phase I/II Study of Neuroendocrine Dysfunction in Patients With Closed Head Injuries	nan	UNKNOWN
Improvement of Laboratory Diagnostics in Hypothyroid Patients Using Levothyroxine	nan	RECRUITING
NOMOTHETICOS: Nonlinear Modelling of Thyroid Hormones' Effect on Thyrotropin Incretion in Confirmed Open-loop Situation	nan	UNKNOWN
TSH Receptor Mutations Among a Consanguineous Community	nan	COMPLETED
Observational Study With Prospective and/or Retrospective Follow-up, Without Modifying Patient Treatment and Follow-up Practices for the Initial Treatment of Hypothyroidism in France	nan	COMPLETED
OnT4-Thyroglobulin Assay Before rhTSH-Aided Radioiodine Ablation	nan	COMPLETED
Register for Patients With Thyroid Hormone Resistance.	nan	RECRUITING
Mechanistic Study of Subclinical Hypothyroidism In the Elderly	nan	COMPLETED
Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3	nan	COMPLETED
Effects of Thyroid Hormone Enzyme Blocking on Hypothyroidism	nan	WITHDRAWN
Study of the Effect of Growth Hormone-Releasing Hormone Antagonist on Growth Hormone Release in Acromegaly	nan	COMPLETED
Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects	nan	RECRUITING
Impact of Thyroid Hormones on Human Glucose and Energy Metabolism	nan	RECRUITING
Correlation Between TCM Syndrome Factors and TSH Changes of Thyroid Hormone Withdrawal Before Iodine Therapy in Postoperative Patients With Thyroid Cancer	nan	UNKNOWN
Analysis of Chlordecone Tissue Concentrations in Patients Treated for Thyroid Surgery at Guadeloupe University Hospital	nan	NOT_YET_RECRUITING
Thyroid Dysfunction in Patients With Major Psychiatric Disorders	nan	UNKNOWN
Metabolomics of Thyroid Hormones	nan	COMPLETED
ThyrOp: A Study of Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic Goiter	nan	UNKNOWN
Observation in the Treatment of Graves' Disease	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a TRHDE binder may also engage these)

Protein	Name	Similarity
Q10836	—	1.000	Q10836 →
Q8K093	—	1.000	Q8K093 →
Q8IWK6	—	0.953	Q8IWK6 →
Q8BG28	—	0.950	Q8BG28 →
Q86X52	—	0.948	Q86X52 →
Q6QNK2	—	0.948	Q6QNK2 →
Q8BFR2	—	0.948	Q8BFR2 →
Q7TT36	—	0.948	Q7TT36 →
Q9JL27	—	0.946	Q9JL27 →
Q80T32	—	0.945	Q80T32 →
Q99J86	—	0.945	Q99J86 →
P61811	—	0.944	P61811 →
Q7TT15	—	0.943	Q7TT15 →
Q8N475	—	0.943	Q8N475 →
Q5ZIT8	—	0.943	Q5ZIT8 →
Q6ZQ11	—	0.943	Q6ZQ11 →
P21214	—	0.942	P21214 →
Q38L25	—	0.942	Q38L25 →
ITGB8	Integrin beta-8	0.941	landscape →
MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.941	landscape →
Q03351	—	0.941	Q03351 →
Q6IS24	—	0.941	Q6IS24 →
P27090	—	0.940	P27090 →
P26013	—	0.940	P26013 →
Q8NCR0	—	0.940	Q8NCR0 →
Q8WU66	—	0.940	Q8WU66 →
J3S6Y1	—	0.940	J3S6Y1 →
Q6P1X5	—	0.939	Q6P1X5 →
O77485	—	0.939	O77485 →
Q15223	—	0.939	Q15223 →