Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 15/20 | 0.58 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8245606 | 0.94 | HIF1A (0.56) | HIF1AEGLN3EGLN1L3MBTL1EGLN2 | |
| SCHEMBL8248316 | 0.93 | HIF1A (0.55) | HIF1AEGLN3EGLN1L3MBTL1EGLN2 | |
| SCHEMBL8248071 | 0.86 | HIF1A (0.56) | HIF1AEGLN3EGLN1L3MBTL1 | |
| SCHEMBL8243641 | 0.85 | HIF1A (0.67) | HIF1AEGLN3EGLN1EGLN2 | |
| SCHEMBL2382549 | 0.84 | HIF1A (0.72) | HIF1AEGLN1 | |
| SCHEMBL8237955 | 0.84 | EGLN1 (0.64) | HIF1AEGLN3EGLN1L3MBTL1 | |
| SCHEMBL8247183 | 0.83 | HIF1A (0.62) | HIF1AEGLN3EGLN1EGLN2 | |
| SCHEMBL8245604 | 0.82 | HIF1A (0.61) | HIF1AEGLN3EGLN1EGLN2 | |
| SCHEMBL8247330 | 0.82 | EGLN1 (0.65) | HIF1AEGLN3EGLN1L3MBTL1EGLN2 | |
| SCHEMBL8244124 | 0.82 | EGLN1 (0.59) | HIF1AEGLN3EGLN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |