Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.54 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241916 | 0.95 | TRPC5 (0.49) | TRPC5DHFRNPSR1TDP1ALDH1A1 | |
| SCHEMBL8250142 | 0.93 | TRPC5 (0.54) | TRPC5DHFRNPSR1TDP1ALDH1A1 | |
| SCHEMBL8250779 | 0.89 | TRPC5 (0.49) | TRPC5DHFRNPSR1TDP1ALDH1A1 | |
| SCHEMBL14007607 | 0.87 | TRPC5 (0.56) | TRPC5DHFRNPSR1TDP1ALDH1A1 | |
| SCHEMBL8284404 | 0.87 | TRPC5 (0.40) | TRPC5DHFRNPSR1TDP1ALDH1A1 | |
| SCHEMBL8253656 | 0.86 | TRPC5 (0.52) | TRPC5DHFRNPSR1TDP1ALDH1A1 | |
| SCHEMBL14002725 | 0.86 | TRPC5 (0.47) | TRPC5DHFRNPSR1TDP1ALDH1A1 | |
| SCHEMBL8252768 | 0.86 | TRPC5 (0.63) | TRPC5DHFRNPSR1TDP1ALDH1A1 | |
| SCHEMBL8285136 | 0.83 | TRPC5 (0.47) | TRPC5NPSR1TDP1ALDH1A1MEN1 | |
| SCHEMBL14002615 | 0.83 | TRPC5 (0.49) | TRPC5DHFRNPSR1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006136561-A1 | 1- ( 2-AMINO-3- (SUBSTITUTED ALKYL)-3H-BENZIMIDAZOIYLMETHYL) -3-SUBTITUTED-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES WITH ACTIVITY ON RESPIRATORY SYNCYTIAL VIRUS | TIBOTEC PHARMACEUTICALS LTD (IE) | 2006-12-28 | — | — | WO | disclosed |