Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.49 |
| ▸ | PGR | P06401 | 9/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4636657 | 0.99 | OPRM1 (0.48) | OPRM1PGROPRL1HTR3AHTR4 | |
| SCHEMBL4669069 | 0.88 | OPRM1 (0.54) | OPRM1PGROPRL1CHRM2CHRM4 | |
| SCHEMBL607661 | 0.85 | OPRM1 (0.56) | OPRM1PGRCHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL606145 | 0.84 | OPRM1 (0.55) | OPRM1PGRCHRM2CHRM4CHRM5 | |
| SCHEMBL4307479 | 0.84 | OPRM1 (0.51) | OPRM1PGROPRL1HTR3AHTR4 | |
| SCHEMBL31285927 | 0.84 | OPRM1 (0.51) | OPRM1PGROPRL1HTR3AHTR4 | |
| SCHEMBL4637224 | 0.81 | CHRM1 (0.67) | OPRM1OPRL1CHRM2CHRM4CHRM5 | |
| SCHEMBL4635947 | 0.81 | CCR5 (0.49) | OPRM1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5385477 | 0.81 | OPRM1 (0.53) | OPRM1PGRCHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL4635701 | 0.80 | CHRM1 (0.66) | OPRM1OPRL1CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288413-B2 | Benzimidazolones which have activity at M1 receptor | GLAXO GROUP LIMITED (GB) | 2012-10-16 | — | — | US | disclosed |
| US-8288413-B2 | Benzimidazolones which have activity at M1 receptor | GLAXO GROUP LIMITED (GB) | 2012-10-16 | — | — | US | disclosed |
| US-20080306112-A1 | Benzimidazolones Which Have Activity at M1 Receptor | GLAXO GROUP LIMITED (GB) | 2008-12-11 | — | — | US | disclosed |
| US-20080306112-A1 | Benzimidazolones Which Have Activity at M1 Receptor | GLAXO GROUP LIMITED (GB) | 2008-12-11 | — | — | US | disclosed |
| WO-2007036711-A1 | BENZIMIDAZOLONES WHICH HAVE ACTIVITY AT Ml RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306112-A1 | Benzimidazolones Which Have Activity at M1 Receptor | CHRM1, CHRM2, CHRM4 | OPRM1 11/4885PGR 788/4885OPRL1 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.