Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247376 | 0.84 | TP53 (0.36) | KDM4EKMT2AGAAMEN1TDP1 | |
| SCHEMBL8256933 | 0.82 | KDM4E (0.41) | KDM4EKMT2AMAPTMEN1TDP1 | |
| SCHEMBL8247720 | 0.81 | ALDH1A1 (0.40) | KDM4EKMT2AMAPTGAAMEN1 | |
| SCHEMBL8254302 | 0.76 | TYK2 (0.51) | KDM4EKMT2AMAPTGAAL3MBTL1 | |
| SCHEMBL8247377 | 0.76 | KMT2A (0.44) | KDM4EKMT2AMAPTAURKACSF1R | |
| SCHEMBL8253069 | 0.72 | KDM4E (0.44) | KDM4EKMT2AMAPTTDP1L3MBTL1 | |
| SCHEMBL8246395 | 0.72 | ALDH1A1 (0.46) | KDM4EKMT2AAURKACSF1RRET | |
| SCHEMBL8255673 | 0.72 | MEN1 (0.33) | KMT2AMEN1TDP1 | |
| SCHEMBL10164346 | 0.71 | HSD17B10 (0.46) | KDM4EKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL351286 | 0.70 | F2 (0.40) | KDM4EKMT2AMAPTAURKACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006128184-A2 | PYRIMIDINE OR TRIAZINE FUSED BICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS-PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |