⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5738965 | 0.80 | — | — | |
| SCHEMBL3695983 | 0.77 | CES1 (0.43) | — | |
| SCHEMBL133684 | 0.76 | — | — | |
| SCHEMBL10432950 | 0.75 | TSHR (0.30) | — | |
| SCHEMBL1705025 | 0.73 | CES2 (0.53) | — | |
| SCHEMBL15716465 | 0.73 | — | — | |
| SCHEMBL4283092 | 0.72 | — | — | |
| Butane SCHEMBL3248202 | 0.72 | HDAC1 (0.39) | — | |
| SCHEMBL27720460 | 0.72 | — | — | |
| SCHEMBL22803486 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12577247-B2 | Diaminopyrazolo[1,5-a]pyrimidine-6-carbonitrile compounds as adenosine 2A receptor and adenosine 2B receptor antagonist | Bugworks Research, Inc. (US) | 2026-03-17 | — | — | US | disclosed |
| WO-2024017266-A1 | POLYMORPHIC FORM OF GLP-1R AGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF | 德睿智药(苏州)新药研发有限公司 | 2024-01-25 | — | — | WO | disclosed |
| CN-117417329-A | Polymorphic substance of GLP-1R agonist as well as preparation method and application thereof | 德睿智药(苏州)新药研发有限公司 | 2024-01-19 | — | — | CN | disclosed |
| US-20230167119-A1 | DIAMINOPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBONITRILE COMPOUNDS AS ADENOSINE 2A RECEPTOR AND ADENOSINE 2B RECEPTOR ANTAGONIST | Bugworks Research, Inc. | 2023-06-01 | — | — | US | disclosed |
| US-20230167119-A1 | DIAMINOPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBONITRILE COMPOUNDS AS ADENOSINE 2A RECEPTOR AND ADENOSINE 2B RECEPTOR ANTAGONIST | Bugworks Research, Inc. | 2023-06-01 | — | — | US | disclosed |
| CN-115867553-A | Diaminopyrazolo [1,5-a ] pyrimidine-6-carbonitrile compounds as adenosine 2A receptor and adenosine 2B receptor antagonists | 巴格沃克斯研究有限公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-4121431-A1 | DIAMINOPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBONITRILE COMPOUNDS AS ADENOSINE 2A RECEPTOR AND ADENOSINE 2B RECEPTOR ANTAGONIST | Bugworks Research, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| WO-2022149167-A1 | DIAMINOPYRAZOLO[1,5-A]PYRIMIDINE-6-CARBONITRILE COMPOUNDS AS ADENOSINE 2A RECEPTOR AND ADENOSINE 2B RECEPTOR ANTAGONIST | BUGWORKS RESEARCH INDIA PVT LTD (IN) | 2022-07-14 | — | — | WO | disclosed |
| US-20180282339-A1 | PROCESS FOR THE PREPARATION OF THE AMORPHOUS FORM OF IBRUTINIB AND NOVEL CRYSTALLINE FORM | OLON SPA (IT) | 2018-10-04 | — | — | US | disclosed |
| EP-3377498-A1 | PROCESS FOR THE PREPARATION OF THE AMORPHOUS FORM OF IBRUTINIB AND NOVEL CRYSTALLINE FORM | OLON S.p.A. (IT) | 2018-09-26 | — | — | EP | disclosed |
| CN-1678576-A | Pyrrolidine derivatives as oxytocin antagonists | APPLIED RESEARCH SYSTEMS (AN) | 2005-10-05 | — | — | CN | disclosed |
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |
| US-4565761-A | Electrophotographic process utilizing an azulenium salt-containing photosensitive member | CANON KABUSHIKI KAISHA (JP) | 1986-01-21 | — | — | US | disclosed |
| US-4548886-A | ELECTROGRAPHIC FILMS; OPTICAL RECORDING MEDIA | CANON KABUSHIKI KAISHA (JP) | 1985-10-22 | — | — | US | disclosed |
| EP-0070133-A2 | Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application | BEECHAM GROUP PLC (GB) | 1983-01-19 | — | — | EP | disclosed |
| US-4234734-A | 2,2,6,6-Tetramethylpiperidine derivatives | CIBA-GEIGY CORPORATION (US) | 1980-11-18 | — | — | US | disclosed |