Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 5/20 | 0.38 |
| ▸ | KIF11 | P52732 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11776858 | 0.98 | KDM4E (0.50) | KDM4EPKMHTR2AKIF11MAPT | |
| Benzoic Acid SCHEMBL11773028 | 0.86 | TSHR (0.45) | KDM4EPKMKIF11MAPTGAA | |
| SCHEMBL11778850 | 0.85 | KDM4E (0.41) | KDM4EPKMHTR2AKIF11PDK2 | |
| SCHEMBL11777445 | 0.81 | KDM4E (0.41) | KDM4EPKMKIF11TAAR1PDK2 | |
| SCHEMBL7326617 | 0.78 | KDM4E (0.56) | KDM4EPKMKIF11MAPTGAA | |
| SCHEMBL11773946 | 0.78 | KDM4E (0.47) | KDM4EPKMHTR2AKIF11MAPT | |
| SCHEMBL11816306 | 0.75 | KDM4E (0.45) | KDM4EPKMKIF11 | |
| SCHEMBL7827435 | 0.74 | PKM (0.47) | KDM4EPKMKIF11MAPTALDH1A1 | |
| SCHEMBL11616386 | 0.74 | KDM4E (0.47) | KDM4EPKMKIF11MAPTGAA | |
| SCHEMBL11777057 | 0.74 | KDM4E (0.51) | KDM4EPKMHTR2AKIF11MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7807841-B2 | Spiro-containing compounds and compositions as modulators of steroid hormone nuclear receptors | IRM LLC (BM) | 2010-10-05 | — | — | US | disclosed |
| US-7807841-B2 | Spiro-containing compounds and compositions as modulators of steroid hormone nuclear receptors | IRM LLC (BM) | 2010-10-05 | — | — | US | disclosed |
| US-20090124597-A1 | SPIRO-CONTAINING COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | IRM LLC (BM) | 2009-05-14 | — | — | US | disclosed |
| US-20090124597-A1 | SPIRO-CONTAINING COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | IRM LLC (BM) | 2009-05-14 | — | — | US | disclosed |
| WO-2006104594-A2 | SPIRO-CONTAINING COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | IRM LLC (BM) | 2006-10-05 | — | — | WO | disclosed |
| US-3994918-A | ANTICONVULSANTS, TRANQUILIZERS | SANDOZ, INC. (US) | 1976-11-30 | — | — | US | disclosed |
| US-3868463-A | Method of treating arrhythmia | REMY DAVID C | 1975-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124597-A1 | SPIRO-CONTAINING COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | NR3C2, NR5A1, ESRRA | KDM4E 4170/4885PKM 1645/4885HTR2A 1603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.