Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911350 | 1.00 | NR1H2 (0.40) | NR1H2USP2SMN1; SMN2DDB1CRBN | |
| SCHEMBL25845322 | 0.81 | NR1H2 (0.44) | NR1H2USP2SMN1; SMN2DDB1CRBN | |
| SCHEMBL202938 | 0.77 | USP2 (0.50) | NR1H2USP2SMN1; SMN2DDB1CRBN | |
| SCHEMBL19167224 | 0.73 | NR1H2 (0.46) | NR1H2USP2SMN1; SMN2DDB1CRBN | |
| SCHEMBL656014 | 0.73 | DDB1 (0.44) | NR1H2USP2SMN1; SMN2DDB1CRBN | |
| SCHEMBL8105173 | 0.72 | NR1H2 (0.39) | NR1H2USP2SMN1; SMN2NAMPTKDM4E | |
| SCHEMBL8255912 | 0.71 | NR1H2 (0.43) | NR1H2USP2SMN1; SMN2DDB1CRBN | |
| SCHEMBL31424868 | 0.71 | MEN1 (0.45) | NR1H2USP2SMN1; SMN2DDB1CRBN | |
| SCHEMBL2732461 | 0.71 | NR1H2 (0.40) | NR1H2USP2SMN1; SMN2DDB1CRBN | |
| SCHEMBL9058440 | 0.71 | NR1H2 (0.38) | NR1H2USP2SMN1; SMN2NAMPTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006117183-A1 | 3 -M0N0- AND 3 , 5-DISUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2006-11-09 | — | — | WO | disclosed |