Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8105173 | 0.75 | NR1H2 (0.39) | NR1H2USP2SMN1; SMN2NAMPTATM | |
| SCHEMBL16646516 | 0.72 | PDK1 (0.40) | NR1H2GPR119SMN1; SMN2ATMALDH1A1 | |
| SCHEMBL8256483 | 0.71 | NR1H2 (0.40) | NR1H2USP2SMN1; SMN2NAMPTATM | |
| SCHEMBL1911350 | 0.71 | NR1H2 (0.40) | NR1H2USP2SMN1; SMN2NAMPTATM | |
| SCHEMBL20967759 | 0.70 | GPR119 (0.51) | NR1H2GPR119USP2SMN1; SMN2HTT | |
| SCHEMBL19347040 | 0.70 | GPR119 (0.51) | NR1H2GPR119USP2SMN1; SMN2HTT | |
| SCHEMBL202938 | 0.69 | USP2 (0.50) | NR1H2GPR119USP2SMN1; SMN2MAPT | |
| SCHEMBL25819368 | 0.69 | GPR119 (0.56) | GPR119USP2SMN1; SMN2HTTNPC1 | |
| SCHEMBL25819386 | 0.69 | GPR119 (0.56) | GPR119USP2SMN1; SMN2HTTNPC1 | |
| SCHEMBL13600068 | 0.69 | GPR119 (0.56) | GPR119USP2SMN1; SMN2HTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996010034-A2 | THIOL-FREE INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |