Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16646516 | 0.85 | PDK1 (0.40) | NR1H2SMN1; SMN2KDM4EMAPTTHRB | |
| SCHEMBL9058440 | 0.75 | NR1H2 (0.38) | NR1H2USP2SMN1; SMN2MAPTNAMPT | |
| SCHEMBL16633633 | 0.74 | PTPN1 (0.44) | SMN1; SMN2KDM4ETHRBNAMPT | |
| SCHEMBL16633630 | 0.74 | PTPN1 (0.44) | SMN1; SMN2KDM4ETHRBNAMPT | |
| SCHEMBL15297794 | 0.74 | NR1H2 (0.54) | NR1H2USP2SMN1; SMN2MAPTNAMPT | |
| SCHEMBL9183603 | 0.74 | NR1H2 (0.42) | NR1H2USP2SMN1; SMN2KDM4EMAPT | |
| SCHEMBL2732461 | 0.73 | NR1H2 (0.40) | NR1H2USP2SMN1; SMN2KDM4EMAPT | |
| SCHEMBL8256483 | 0.72 | NR1H2 (0.40) | NR1H2USP2SMN1; SMN2KDM4EMAPT | |
| SCHEMBL1911350 | 0.72 | NR1H2 (0.40) | NR1H2USP2SMN1; SMN2KDM4EMAPT | |
| SCHEMBL202938 | 0.70 | USP2 (0.50) | NR1H2USP2SMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986302-A1 | A METHOD OF TREATING CANCER | Merck & Co., Inc. (US) | 2000-03-22 | — | — | EP | disclosed |
| EP-0812203-A4 | INHIBITORS OF GERANYLGERANYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-04-14 | — | — | EP | disclosed |
| EP-0725650-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-02-03 | — | — | EP | disclosed |
| WO-1998054966-A1 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 1998-12-10 | — | — | WO | disclosed |
| EP-0836383-A1 | COMBINATIONS OF INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-04-22 | — | — | EP | disclosed |
| EP-0812203-A1 | INHIBITORS OF GERANYLGERANYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-12-17 | — | — | EP | disclosed |
| EP-0783517-A2 | THIOL-FREE INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| EP-0725650-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1996-08-14 | — | — | EP | disclosed |
| EP-0666844-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1995020396-A1 | INHIBITORS OF GERANYLGERANYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1995-08-03 | — | — | WO | disclosed |