Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.33 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.32 |
| ▸ | RPS27 | P42677 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL826074 | 0.83 | CHEK2 (0.39) | CHEK2AGPAT2RPS27MAPK8MAPK1 | |
| SCHEMBL826092 | 0.82 | CHEK2 (0.36) | CHEK2AGPAT2RPS27MAPK8MAPK1 | |
| SCHEMBL825976 | 0.78 | CHEK2 (0.36) | CHEK2AGPAT2RPS27MAPK8MAPK1 | |
| SCHEMBL825914 | 0.76 | CHEK2 (0.34) | CHEK2AGPAT2RPS27MAPK8MAPK1 | |
| SCHEMBL4425330 | 0.75 | CHEK2 (0.45) | CHEK2AGPAT2RPS27MAPK8MAPK1 | |
| SCHEMBL4414487 | 0.74 | MAP4K4 (0.45) | CHEK2MAPK8DHFR | |
| SCHEMBL5122635 | 0.70 | CTNNB1 (0.36) | MAPK1 | |
| SCHEMBL4530939 | 0.69 | HSP90AA1 (0.35) | MAPK1DHFR | |
| SCHEMBL4523975 | 0.69 | MAPT (0.37) | DHFR | |
| SCHEMBL4412814 | 0.68 | MET (0.40) | CHEK2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143394-B2 | Pyrido(3,2-d)pyrimidines useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2012-03-27 | — | — | US | disclosed |