Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 6/20 | 0.39 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | RPS27 | P42677 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 3/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL826092 | 0.84 | CHEK2 (0.36) | CHEK2AGPAT2MAPK1MAPK8RPS27 | |
| SCHEMBL825976 | 0.83 | CHEK2 (0.36) | CHEK2AGPAT2MAPK1MAPK8RPS27 | |
| SCHEMBL825914 | 0.83 | CHEK2 (0.34) | CHEK2AGPAT2MAPK1MAPK8RPS27 | |
| SCHEMBL825682 | 0.83 | CHEK2 (0.35) | CHEK2AGPAT2MAPK1MAPK8RPS27 | |
| SCHEMBL4425330 | 0.80 | CHEK2 (0.45) | CHEK2AGPAT2MAPK1MAPK8RPS27 | |
| SCHEMBL4414487 | 0.79 | MAP4K4 (0.45) | CHEK2MAPK8DHFRMAPK9MAPK10 | |
| SCHEMBL823718 | 0.71 | MAP4K4 (0.41) | CHEK2MAPK8MAPK9 | |
| SCHEMBL4412814 | 0.71 | MET (0.40) | CHEK2MAPK1HSD17B10 | |
| SCHEMBL823761 | 0.70 | MKNK2 (0.38) | CHEK2AGPAT2MAPK8DHFRMAPK9 | |
| SCHEMBL4524543 | 0.70 | MAPT (0.55) | AGPAT2DHFRHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143394-B2 | Pyrido(3,2-d)pyrimidines useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2012-03-27 | — | — | US | disclosed |