Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 2/20 | 0.55 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.55 |
| ▸ | ACE | P12821 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 6/20 | 0.48 |
| ▸ | PPARG | P37231 | 5/20 | 0.48 |
| ▸ | CTSS | P25774 | 7/20 | 0.47 |
| ▸ | CTSK | P43235 | 6/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20556410 | 1.00 | ITGA4 (0.55) | ITGA4ITGB7ACEITGB3ITGA2B | |
| SCHEMBL20556571 | 0.91 | KLK5 (0.51) | ITGA4ITGB7ACEITGB3ITGA2B | |
| SCHEMBL12706536 | 0.91 | KLK5 (0.51) | ITGA4ITGB7ACEITGB3ITGA2B | |
| SCHEMBL27144946 | 0.91 | ACE (0.55) | ITGA4ITGB7ACEITGB3ITGA2B | |
| SCHEMBL29641697 | 0.91 | ACE (0.55) | ITGA4ITGB7ACEITGB3ITGA2B | |
| SCHEMBL24495424 | 0.91 | ACE (0.55) | ITGA4ITGB7ACEITGB3ITGA2B | |
| SCHEMBL29641706 | 0.91 | ACE (0.55) | ITGA4ITGB7ACEITGB3ITGA2B | |
| SCHEMBL24489606 | 0.91 | ACE (0.55) | ITGA4ITGB7ACEITGB3ITGA2B | |
| SCHEMBL29726545 | 0.89 | LDHA (0.58) | ITGA4ITGB7ACEITGB3ITGA2B | |
| SCHEMBL2675545 | 0.89 | LDHA (0.58) | ITGA4ITGB7ACEITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1865950-B1 | COMPOUNDS USEFUL AS MODULATORS OF THE PROTEASOME ACTIVITY | CENTRE NAT RECH SCIENT (FR) | 2013-08-28 | — | — | EP | disclosed |
| US-7919468-B2 | Compounds useful as modulators of the proteasome activity | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2011-04-05 | — | — | US | disclosed |
| US-20090069222-A1 | Compounds Useful as Modulators of the Proteasome Activity | CENTRE NATIONAL DE AL RECHERCHE SCIENTIFIQUE (FR) | 2009-03-12 | — | — | US | disclosed |
| WO-2006105811-A1 | COMPOUNDS USEFUL AS MODULATORS OF THE PROTEASOME ACTIVITY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2006-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069222-A1 | Compounds Useful as Modulators of the Proteasome Activity | PSMB10, PSMB11, PSMB6 | ITGA4 4343/4885ITGB7 4267/4885ACE 2284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.