Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxypurinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxypurinol SCHEMBL2017937 | 0.67 | GDA (0.41) | KDM4EKMT2A | |
| SCHEMBL31359458 | 0.61 | PARP1 (0.55) | KDM4EKMT2A | |
| SCHEMBL2128369 | 0.56 | TYRO3 (0.32) | — | |
| SCHEMBL20550703 | 0.56 | ADORA2A (0.56) | KDM4EKMT2A | |
| SCHEMBL3167524 | 0.56 | — | — | |
| Hydrochloric Acid SCHEMBL20551365 | 0.55 | ADORA2A (0.55) | KDM4EKMT2A | |
| Oxypurinol SCHEMBL8256863 | 0.54 | ALDH1A1 (0.53) | — | |
| SCHEMBL31210501 | 0.54 | MAPK1 (0.36) | — | |
| SCHEMBL8278866 | 0.54 | PARP1 (0.46) | KDM4E | |
| Oxypurinol SCHEMBL2077651 | 0.53 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006083687-A1 | CRYSTAL SALT OF XANTHINE OXIDASE INHIBITORS | CARDIOME PHARMA CORP. (CA) | 2006-08-10 | — | — | WO | disclosed |