Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 11/20 | 0.55 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.35 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8258486 | 0.92 | IL2 (0.46) | IL2ABL1 | |
| SCHEMBL8258543 | 0.87 | IL2 (0.50) | IL2STIM1ORAI1ABL1ORAI2 | |
| SCHEMBL8260163 | 0.87 | IL2 (0.56) | IL2STIM1ORAI1ABL1ORAI2 | |
| SCHEMBL8256460 | 0.87 | IL2 (0.56) | IL2STIM1ORAI1ABL1ORAI2 | |
| SCHEMBL8263040 | 0.83 | IL2 (0.46) | IL2STIM1ORAI1ABL1CRACR2A | |
| SCHEMBL5555307 | 0.83 | IL2 (0.63) | IL2STIM1ORAI1ABL1ORAI2 | |
| SCHEMBL8260142 | 0.82 | IL2 (0.56) | IL2STIM1ORAI1ABL1ORAI2 | |
| SCHEMBL5554263 | 0.82 | IL2 (0.62) | IL2STIM1ORAI1ABL1 | |
| SCHEMBL8260159 | 0.81 | IL2 (0.55) | IL2STIM1ORAI1ABL1ORAI2 | |
| SCHEMBL15395972 | 0.81 | IL2 (0.67) | IL2ABL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081391-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |