Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 7/20 | 0.46 |
| ▸ | STIM1 | Q13586 | 3/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.33 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.33 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.33 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8263029 | 0.92 | IL2 (0.44) | IL2ABL1IKBKETBK1 | |
| SCHEMBL8263031 | 0.89 | IL2 (0.55) | IL2STIM1ORAI1ABL1 | |
| SCHEMBL8262099 | 0.87 | IL2 (0.47) | IL2STIM1ORAI1ABL1TRPC1 | |
| SCHEMBL8262623 | 0.83 | IL2 (0.46) | IL2STIM1ORAI1ABL1TRPC1 | |
| SCHEMBL8258483 | 0.83 | IL2 (0.55) | IL2STIM1ORAI1ABL1CRACR2A | |
| SCHEMBL8263043 | 0.82 | IL2 (0.49) | IL2STIM1ORAI1ABL1TRPC1 | |
| SCHEMBL8262993 | 0.81 | IL2 (0.47) | IL2STIM1ORAI1ABL1TRPC1 | |
| SCHEMBL8262107 | 0.79 | IL2 (0.45) | IL2ABL1IKBKETBK1 | |
| SCHEMBL8264012 | 0.79 | IL2 (0.49) | IL2ABL1 | |
| SCHEMBL8263038 | 0.78 | IL2 (0.42) | IL2ORAI1TRPC3CRACR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081389-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |