Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 18/20 | 0.60 |
| ▸ | MMP13 | P45452 | 18/20 | 0.60 |
| ▸ | MMP1 | P03956 | 17/20 | 0.60 |
| ▸ | ADAM17 | P78536 | 12/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568460 | 0.85 | MMP9 (0.81) | MMP9MMP13MMP1ADAM17 | |
| Hydroxyamine SCHEMBL7554863 | 0.83 | MMP9 (0.78) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL6566736 | 0.83 | MMP9 (0.81) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL6567121 | 0.82 | MMP1 (0.80) | MMP9MMP13MMP1ADAM17MEN1 | |
| SCHEMBL6565359 | 0.80 | MMP9 (0.80) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL6566730 | 0.78 | MMP9 (0.74) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL6567493 | 0.78 | MMP1 (0.79) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL6567668 | 0.77 | MMP9 (0.76) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL6565358 | 0.77 | MMP1 (0.83) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL6565426 | 0.77 | MMP1 (0.80) | MMP9MMP13MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973512-A1 | N-HYDROXY-2-(ALKYL, ARYL OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998037877-A1 | N-HYDROXY-2-(ALKYL, ARYL OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-09-03 | — | — | WO | disclosed |