Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | BPTF | Q12830 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4325141 | 0.86 | MEN1 (0.38) | FPR2MEN1KMT2ARAB9ANPSR1 | |
| SCHEMBL4318567 | 0.84 | FPR2 (0.54) | FPR2MEN1KMT2ANPSR1THRB | |
| SCHEMBL5264271 | 0.84 | MEN1 (0.36) | FPR2MEN1KMT2ARAB9ANPSR1 | |
| SCHEMBL4318702 | 0.79 | KMT2A (0.51) | FPR2MEN1KMT2ARAB9ATHRB | |
| SCHEMBL1259421 | 0.78 | FPR2 (0.42) | FPR2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8258475 | 0.75 | ALDH1A1 (0.47) | FPR2MEN1KMT2ARAB9ANPSR1 | |
| SCHEMBL4332386 | 0.75 | SMO (0.54) | HTTMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4327601 | 0.74 | SMN1; SMN2 (0.47) | RAB9ANPSR1ALDH1A1NPC1LMNA | |
| SCHEMBL1258186 | 0.74 | KMT2A (0.46) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL4334363 | 0.73 | FPR2 (0.41) | FPR2MEN1KMT2ARAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006071730-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2006-07-06 | — | — | WO | disclosed |