Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.52 |
| ▸ | ANPEP | P15144 | 1/20 | 0.52 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.52 |
| ▸ | GHSR | Q92847 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | IL1RN | P18510 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8251294 | 1.00 | ERAP2 (0.52) | ERAP2ANPEPERAP1GHSRMEN1 | |
| SCHEMBL8248386 | 0.94 | GHSR (0.53) | ERAP2ANPEPERAP1GHSR | |
| SCHEMBL8257540 | 0.94 | GHSR (0.53) | ERAP2ANPEPERAP1GHSR | |
| SCHEMBL12433263 | 0.88 | ERAP2 (0.56) | ERAP2ANPEPERAP1GHSRMEN1 | |
| SCHEMBL13852888 | 0.88 | ERAP2 (0.56) | ERAP2ANPEPERAP1GHSRMEN1 | |
| SCHEMBL8254030 | 0.88 | CCKBR (0.49) | ERAP2ANPEPERAP1 | |
| SCHEMBL13852889 | 0.83 | GHSR (0.56) | ERAP2ANPEPERAP1GHSR | |
| SCHEMBL13852890 | 0.83 | GHSR (0.56) | ERAP2ANPEPERAP1GHSR | |
| SCHEMBL12433274 | 0.81 | GHSR (0.59) | ERAP2ANPEPERAP1GHSR | |
| SCHEMBL13853026 | 0.81 | GHSR (0.59) | ERAP2ANPEPERAP1GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899365-B1 | ANGIOTENSIN I-CONVERTING ENZYME (ACE) INHIBITORS | UNIV CAPE TOWN (ZA) | 2012-09-12 | — | — | EP | disclosed |
| US-7981922-B2 | Angiotensin I-converting enzyme (ACE) inhibitors | UNIVERSITY OF CAPE TOWN (ZA) | 2011-07-19 | — | — | US | disclosed |
| WO-2006126087-A2 | ANGIOTENSIN I-CONVERTING ENZYME (ACE) INHIBITORS | UNIVERSITY OF CAPE TOWN (ZA) | 2006-11-30 | — | — | WO | disclosed |