Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 13/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 13/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 13/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8259582 | 0.90 | ALDH1A1 (0.41) | ADRA1DADRA1AADRA1BMAPTHTR1A | |
| SCHEMBL4334313 | 0.83 | ADRA1D (0.43) | ADRA1DADRA1AADRA1BKDM4EMAPT | |
| SCHEMBL4324270 | 0.80 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BKDM4EMAPT | |
| SCHEMBL4328117 | 0.80 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BKDM4EMAPT | |
| SCHEMBL4318684 | 0.79 | MAPT (0.51) | ADRA1DADRA1AADRA1BKDM4EMAPT | |
| SCHEMBL4331760 | 0.78 | ADRA1D (0.55) | ADRA1DADRA1AADRA1BKDM4EMAPT | |
| SCHEMBL8260355 | 0.78 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BKDM4EMAPT | |
| SCHEMBL4319280 | 0.74 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BKDM4EMAPT | |
| SCHEMBL4331305 | 0.73 | ALDH1A1 (0.43) | ADRA1DADRA1AADRA1BMAPTHTR1A | |
| SCHEMBL4321301 | 0.73 | MAPK1 (0.47) | ADRA1DADRA1AADRA1BKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006071730-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2006-07-06 | — | — | WO | disclosed |