Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 9/20 | 0.55 |
| ▸ | STIM1 | Q13586 | 3/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.31 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.31 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.31 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.31 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8263040 | 0.89 | IL2 (0.46) | IL2STIM1ORAI1ABL1 | |
| SCHEMBL8261515 | 0.86 | IL2 (0.55) | IL2STIM1ORAI1ABL1KCNQ3 | |
| SCHEMBL8264013 | 0.86 | IL2 (0.60) | IL2STIM1ORAI1ABL1KCNQ3 | |
| SCHEMBL8263029 | 0.84 | IL2 (0.44) | IL2ABL1MAPK13MAPK12MAPK11 | |
| SCHEMBL8262624 | 0.82 | IL2 (0.55) | IL2STIM1ORAI1ABL1KCNQ3 | |
| SCHEMBL8262095 | 0.81 | IL2 (0.58) | IL2STIM1ORAI1ABL1KCNQ3 | |
| SCHEMBL8263038 | 0.80 | IL2 (0.42) | IL2ORAI1 | |
| SCHEMBL8262619 | 0.80 | IL2 (0.56) | IL2STIM1ORAI1ABL1KCNQ3 | |
| SCHEMBL8258543 | 0.79 | IL2 (0.50) | IL2STIM1ORAI1ABL1 | |
| SCHEMBL8263046 | 0.77 | IL2 (0.48) | IL2STIM1ORAI1KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081389-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |