Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 5/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.31 |
| ▸ | CSF1R | P07333 | 2/20 | 0.31 |
| ▸ | POLQ | O75417 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | BLK | P51451 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8263040 | 0.92 | IL2 (0.46) | IL2ABL1IKBKETBK1 | |
| SCHEMBL8264012 | 0.86 | IL2 (0.49) | IL2ABL1MAPK14CSF1RPOLQ | |
| SCHEMBL8262107 | 0.86 | IL2 (0.45) | IL2ABL1IKBKETBK1MAPK14 | |
| SCHEMBL8263031 | 0.84 | IL2 (0.55) | IL2ABL1MAPK14MAPK13MAPK12 | |
| SCHEMBL8262625 | 0.82 | IL2 (0.44) | IL2ABL1IKBKETBK1MAPK14 | |
| SCHEMBL8258486 | 0.82 | IL2 (0.46) | IL2ABL1 | |
| SCHEMBL8262105 | 0.81 | IL2 (0.47) | IL2ABL1IKBKETBK1MAPK14 | |
| SCHEMBL8263038 | 0.80 | IL2 (0.42) | IL2 | |
| SCHEMBL8262099 | 0.79 | IL2 (0.47) | IL2ABL1MAPK14CSF1RLCK | |
| SCHEMBL8263054 | 0.79 | IL2 (0.42) | IL2MAPK14CSF1RPOLQCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081389-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |