Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13177323 | 0.81 | REN (0.67) | RENKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13177128 | 0.79 | REN (1.00) | RENKCNH2CYP3A4HTR1AADRA1D | |
| SCHEMBL2934673 | 0.79 | REN (1.00) | RENKCNH2CYP3A4HTR1AADRA1D | |
| SCHEMBL2929532 | 0.78 | REN (0.67) | RENKCNH2CYP3A4HTR1AADRA1D | |
| SCHEMBL8262709 | 0.78 | REN (0.67) | RENKCNH2CYP3A4HTR1AADRA1D | |
| SCHEMBL8262513 | 0.78 | REN (0.67) | RENKCNH2CYP3A4HTR1AADRA1D | |
| SCHEMBL1911550 | 0.70 | REN (1.00) | RENKCNH2 | |
| SCHEMBL4323431 | 0.70 | SLC6A2 (0.57) | KCNH2CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3487650 | 0.69 | REN (0.56) | RENKCNH2SLC6A2SLC6A4HTR1A | |
| SCHEMBL8263200 | 0.69 | REN (0.54) | RENKCNH2HTR1AADRA1DHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006066896-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2006-06-29 | — | — | WO | disclosed |