SCHEMBL8263239

SCHEMBL8263239

CCOC(=O)C1CN(Cc2ccccc2)CC1(C)C(=O)OCC

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
L3MBTL1 Q9Y468 3/20 0.47
ATM Q13315 1/20 0.47
SIGMAR1 Q99720 2/20 0.46
ALDH1A1 P00352 3/20 0.46
KDM4E B2RXH2 2/20 0.45
GAA P10253 1/20 0.45
LMNA P02545 1/20 0.45
F10 P00742 1/20 0.45
PRSS1 P07477 1/20 0.45
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
USP30 Q70CQ3 1/20 0.44
POLB P06746 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
CCR8 P51685 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4105884 0.86 L3MBTL1 (0.49) CYP3A4CYP2D6CYP2C9CYP2C19L3MBTL1
SCHEMBL3974425 0.85 CYP3A4 (0.49) CYP3A4CYP2D6CYP2C9CYP2C19L3MBTL1
SCHEMBL10306089 0.85 CYP3A4 (0.49) CYP3A4CYP2D6CYP2C9CYP2C19L3MBTL1
SCHEMBL4509900 0.83 ALDH1A1 (0.50) CYP3A4CYP2D6CYP2C9CYP2C19L3MBTL1
SCHEMBL22856259 0.83 ALDH1A1 (0.43) CYP3A4CYP2D6ALDH1A1KDM4EGAA
SCHEMBL17517700 0.83 L3MBTL1 (0.48) CYP3A4CYP2D6CYP2C9CYP2C19L3MBTL1
SCHEMBL20397038 0.83 ALDH1A1 (0.43) CYP3A4CYP2D6ALDH1A1KDM4EGAA
SCHEMBL18668624 0.83 ALDH1A1 (0.43) CYP3A4CYP2D6ALDH1A1KDM4EGAA
SCHEMBL3977998 0.82 CYP3A4 (0.47) CYP3A4CYP2D6CYP2C9CYP2C19L3MBTL1
SCHEMBL10306099 0.82 CYP3A4 (0.47) CYP3A4CYP2D6CYP2C9CYP2C19L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006066896-A2 PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN NOVARTIS AG (CH) 2006-06-29 WO disclosed