Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 5/20 | 0.49 |
| ▸ | POLQ | O75417 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8263054 | 0.92 | IL2 (0.42) | IL2POLQBRAFMAPK14CSF1R | |
| SCHEMBL8262105 | 0.87 | IL2 (0.47) | IL2POLQABL1BRAFMAPK14 | |
| SCHEMBL8263029 | 0.86 | IL2 (0.44) | IL2POLQABL1MAPK14LCK | |
| SCHEMBL8264013 | 0.84 | IL2 (0.60) | IL2ABL1MAPK14MAPK13MAPK12 | |
| SCHEMBL8263042 | 0.82 | IL2 (0.40) | IL2ABL1CSF1R | |
| SCHEMBL8259823 | 0.82 | IL2 (0.46) | IL2POLQABL1BRAF | |
| SCHEMBL8262107 | 0.82 | IL2 (0.45) | IL2POLQABL1MAPK14LCK | |
| SCHEMBL8262625 | 0.81 | IL2 (0.44) | IL2POLQABL1MAPK14LCK | |
| SCHEMBL8263037 | 0.80 | IL2 (0.46) | IL2KDM4ELMNA | |
| SCHEMBL8261524 | 0.80 | IL2 (0.42) | IL2POLQBRAFMAPK14CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081389-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |